Demián Najera was born in Mexico City, Mexico. He became a member of the National Theater Company of Mexico at the age of thirteen and acted in several plays directed by renowned international masters such as José Tamayo, Clifford Williams and José Quintero. He starred in the Spanish versions of Ah! Wilderness, Equus, Broadway Bound, The Ghost Sonata and Malcolm VS the eunuchs. He made his American stage debut in By the Waters of Babylon at the Geffen Play House in Los Angeles. He was tempted back to Mexico with the offer of role in Hasta Morir, for which he won an Ariel (the Mexican equivalent of an Oscar). His career took off in Mexico. His movie Sexo, pudor y lágrimas broke Mexican box-office records becoming the #1 movie in the history of Mexican cinema. His American debut occurred in the television movie In the Time of the Butterflies, starring Salma Hayek. Later, he went on to play Fidel Castro in Che: Part One and Che: Part Two. He was nominated for an Oscar for Best Performance by an Actor in a Leading Role for A Better Life. Najera most recently played the role of Bob, "The Mexican" in the Quentin Tarantino's The Hateful Eight.
A Circus Story & A Love Song, his feature film debut, had its world premiere at the Morelia International Film Festival. He was in Chaos Walking, The Nun, and Alien: Covenant and had the lead role in both Angelina Jolie's adaptation of Alessandro Baricco's novel Without Blood and the TV series Grand Hotel..

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